Molecular determinants of uterine receptivity

I-28: Uterine Receptivity

Uterine Receptivity to Embryo Implantation

It is both flattering and humbling to be asked to address this topic, since quite a few people at this meeting could address it equally well or better. In fact, Koji wrote a review with almost exactly the same title 20 years ago (1). However, each of us would address the area somewhat differently. Over the years I have had the privilege of examining blastocysts and implantation sites of a large...

Potential biochemical markers of uterine receptivity.

Implantation in humans is a complex process that involves embryo apposition and attachment to the maternal endometrial epithelium, traversing adjacent cells of the epithelial lining, and invasion into the endometrial stroma. These processes involve a variety of molecules which are not unique in themselves, but play unique roles in the process of implantation. The molecular dialogue that occurs ...

Transcriptional profiling to address molecular determinants of endometrial receptivity--lessons from studies in livestock species.

The development of a fertilized oocyte into a differentiated multi-cellular organism is a major challenge with regard to the orchestration of the expression of the mammalian genome. Highly complex networks of genes are temporally and spatially regulated during cellular differentiation to generate specific cell types. Embryonic development is critically influenced by external impacts in the fema...

Uterine receptivity to implantation of blastocysts in mammals.

Reproduction in mammals is a highly complex biological process. The critical importance of reproduction to propagation of species required the natural evolution of various strategies that vary considerably across species. Regardless of species, a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus must be established during the peri-im...